Publications of Federico Sesti in reverse chronological order

  1. Sesti F. and A. Bortolami (2020). "Ion channels and the aging brain". Book chapter in "The Neuroscience of Aging", Martin and Preedy editors, Elsevier, in press.
  2. Yu W., M. Shin, F. Sesti (2019). "Complexes formed with integrin-5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling". FASEB J. 33(12):14680-9. doi: 10.1096/fj.201901792R.
  3. Yu W., H. Zhang, M. Shin, F. Sesti (2019). "Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment". Biochem. Biophys. Res. Commun. 512(4):665-9, DOI: 10.1016/j.bbrc.2019.03.130
  4. Wei Y., M. Shin, F. Sesti (2018). "Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer's disease". Cell Death Dis.(2018) 9(8):820 doi: 10.1038/s41419-018-0886-1
  5. F. Sesti , R. Patel (2018). "Cytoskeletal Remodeling during Oxidative and Thermal Stress". Biophys. J. 144(3), 142a-143a.
  6. Patel R., Sriramoji S., Marucci M., Aziz I., Shah S., F. Sesti (2017). "Cytoskeletal Remodeling via Rho GTPases during Oxidative and Thermal Stress in Caenorhabditis elegans ". Biochem. Biophys. Res. Commun. 492(3):338-342.
  7. Yu W., Gowda M., Sharad Y., Singh A.S., F. Sesti (2017). "Oxidation of KCNB1 Potassium Channels Triggers Apoptotic Integrin Signaling in the Brain". Cell Death Dis. 8, e2737; doi:10.1038/cddis.2017.160.
  8. F. Sesti , W. Yu, R. Parakramaweera, J. Alder, S. Thakker-Varia, S. Teng (2017). "Oxidation of K+ Channels in TBI". Biophys. J. 112(3), 547a.
  9. Sesti F. (2017). "Oxidation of Ion Channels in the Aging Process". Book chapter. "Aging: Exploring a Complex Phenomenon", editor S. Ahmad. Taylor and Francis, Boca Raton, FL. October 30, 2017. ISBN 9781138196971.
  10. Yu W., R. Parakramaweera, S. Teng, M. Gowda, Y. Sharad, S. Thakker-Varia, J. Alder, F. Sesti (2016). "Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in Mouse Model of Traumatic Brain Injury". J. Neurosci. 36(43):11084-96.
  11. Patel R. and F. Sesti (2016). "Oxidation of ion channels in the aging nervous system". Brain Res. 1639:174-85.
  12. Sesti F. (2016) "Oxidation of K+ channels in aging and neurodegeneration". invited review Aging and Disease. 7(2):130-5.
  13. Duan Z. and F. Sesti (2015). "Guanine Nucleotide Exchange Factor OSG-1 Confers Functional Aging via Dysregulated Rho Signaling in Caenorhabditis elegans Neurons". Genetics 199(2):487-96.
  14. Sesti F., X. Wu, S. Liu (2014). "Oxidation of KCNB1 K+ channels in central nervous system and beyond". World J Biol Chem 5(2): 85-92.
  15. Iakoubov L., M. Mossakowska, M. Szwed, Z. Duan, F. Sesti, M. Puzianowska-Kuznicka. (2013) "A Common Copy Number Variation (CNV) Polymorphism in the CNTNAP4 Gene: Association with Aging in Females". PLoS ONE 8(11): e79790. doi:10.1371/journal.pone.0079790
  16. Duan Z. and F. Sesti (2013). "A Caenorhabditis elegans model system for amylopathy study". JoVE, (75). doi: 10.3791/50435
  17. Swiatkowski P. and F. Sesti (2013) "Delayed pharyngeal repolarization promotes abnormal calcium buildup in aging muscle". Biochem. Biophys. Res. Commun. 433(3): 354-357.
  18. Cotella D., B. Hernandez-Enriquez, Z. Duan, X. Wu, V.R. Gazula, M.R. Brown, L.K. Kaczmarek., F. Sesti (2013). "An evolutionarily conserved mode of modulation of Shaw-like K+ channels". FASEB J, 27(4):271381-93.
  19. Wu X., B. Hernandez-Enriquez, M. Banas, R. Xu, F. Sesti (2013) "Molecular Mechanisms Underlying the Apoptotic Effect of KCNB1 Oxidation". J. Biol. Chem. 288(6):4128-34.
  20. Cotella D., B. Hernandez, X. Wu, R. Li, Z. Pan, J. Leveille, C. D. Link, S. Oddo, F. Sesti (2012). "Toxic role of K+ channel oxidation in mammalian brain". J. Neurosci., 32(12):4133-44
  21. Cotella D. and ,F. Sesti (2011). "Dynamic Phosphorylation/Dephosphorylation of a Voltage-Gated K+ Channel Controls Non-associative Learning". Biophys. J. 100(3), 99a.
  22. Tutak W., M. Chhowalla, F. Sesti (2010). "The chemical and physical characteristics of single-walled carbon nanotube film impact on osteoblastic cell response". Nanotechnology, 21 (2010) 315102. Featured in: (
  23. Sesti F., S. Cai (2010). "Oxidation of K+ Channels Leads to Progressive Decline in Sensory Function during Ageing". Biophys. J. 98(3), 534a.
  24. Sesti F., S. Liu, S. Cai "Oxidation of K+ channels by ROS: a general mechanism of aging and neurodegeneration?". (2010). Trends in Cell Biology, 20(1):45-51
  25. Cai S., Y. Wang, K. Park, X. Tong, Z. Pan, F. Sesti (2009). "Auto-phosphorylation of a voltage-gated K + channel controls non-associative learning". EMBO J. 28(11):1601-10.
  26. Tutak W., K. Park, G. Fanchini, A. Vasilov, N. Partridge, F. Sesti, M. Chhowalla (2009). "Toxicity induced enhanced extracellular matrix production in osteoblastic cells cultured on single walled carbon nanotube networks". Nanotechnology, 20 (2009) 255101.
  27. Cai S. and F. Sesti (2009). "Oxidation of a potassium channel causes progressive sensory function loss during aging". Nature Neurosci., 12(5):611-7. Featured in: Science Signaling, Vol. 2, Issue 69, p. ec152; C&E News (April 13, 2009 Issue); The medical news (; Home News Tribune; Faculty of 1000 (biology)
  28. Hernandez L., K. Park, F. Sesti (2009) "Electrophysiological recordings in C. elegans nervous and muscle tissue". Book chapter. "Recent Advances in the Neurophysiologic Basis of Disease and Addiction", editors M. Huerta and X. Trujillo pages: 203-214. ISBN: 978-81-308-0359-3
  29. Wang Y. and F. Sesti (2007) "Molecular mechanisms underlying KVS-1-MPS-1 complex assembly" Biophys. J. 93(9):3083-91.
  30. Cai S., W. Li, F. Sesti (2007) "Multiple modes of A-type Potassium current regulation" Current Pharmaceutical Design. 13:3178-84.
  31. Park K. and F. Sesti (2007). "An arrhythmia susceptibility gene in Caenorhabditis elegans" J. Biol. Chem. 282(27):19799-807.
  32. Cai S. and F. Sesti (2007). "A new mode of regulation of N-type inactivation in a Caenorhabditis elegans voltage-gated potassium channel" J. Biol. Chem. 282(25):18597-601.
  33. Hernandez L., K. Park, S. Cai, L. Qin, N. Partridge, F. Sesti (2007) "The antiproliferative role of ERG K+ channels in rat osteoblastic cells". Cell Biochem. Biophys. 47(1):199-208.
  34. S. Cai, K. Park, F. Sesti (2006) "An evolutionarily conserved family of accessory subunits of K+ channels". Cell Biochem. Biophys. 46(1):91-100.
  35. Hernandez L., K. H. Park, F. Sesti(2006). "The mitogenic role of K+ currents in rat UMR 106-01 osteoblastic cells". ACTA PHARMACOLOGICAL SINICA 27, 189-189.
  36. Cai S., L. Hernandez, Y. Wang, K. Park, F. Sesti (2005) "MPS-1 is a K+ channel -subunit and a serine/threonine kinase". Nature Neurosci. 8(11):1503-9. Featured in: C&E News (March 3, 2008 issue)
  37. Chhowalla M., H.E. Unalan, Y. Wang, Z. Iqbal, K. Park, F. Sesti (2005) "Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes". Nanotechnology 16:2982-6.
  38. Park K., S. Cai, L. Hernandez, Y. Wang, F. Sesti. (2005) "A family of K+ channel ancillary subunits regulate taste sensitivity in C. elegans". J. Biol. Chem. 280(23):21893-9
  39. Cai S., Y. Wang, K.H. Park, F. Sesti (2005). "A bifunctional C. elegans protein. MPS1 is a K+ channel beta-subunit and a protein kinase". FASEB J. 19(5), A1158-9.
  40. Park K.H., S. M. Kwok, C. Sharon, R. Baerga, F. Sesti (2004). "N-glycosylation-dependent block is a novel mechanism for drug-induced cardiac arrhythmia". Biophys. J. 86(1), 430A.
  41. Wang Y., K. Park, L. Hernandez, S. Cai, F. Sesti. (2004) "Biophysical and Biomedical Aspects of KCNE Potassium Channel Ancillary Subunits". Recent Res. Dev. Biophys. 3:351-62. ISBN: 81-7895-130-4
  42. Park K., M. Chhowalla, Z. Iqbal, F. Sesti (2003) "Single-walled carbon nanotubes: A new class of ion-channel blockers". J. Biol. Chem. Dec 12;278(50):50212-6
  43. Park K., S. Kwok, C. Sharon, R. Baerga, F. Sesti (2003) "N-glycosylation-dependent block is a novel mechanism for drug-induced cardiac arrhythmia". FASEB J. 15:2308-9.
  44. Chen, H., Sesti, F., S. A. N. Goldstein (2003) "Pore and state-dependent cadmium block of IKs channels formed with MinK-55C and wild type KCNQ1 subunits". Biophys. J. 84(6); 3679-3689
  45. Bianchi L., S. Kwok, M. Driscoll, F. Sesti (2003) "A potassium channel-MiRP complex controls neurosensory function in C. elegans". J. Biol. Chem. 278(14): 12415-24
  46. Sesti F., S. Rajan, R. Gonzalez-Colaso, N. Nikolaeva, S. A. N. Goldstein. (2003) "Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel". Nature Neurosci. 6(4): 353-361
  47. Bianchi L., S.M. Kwok, M. Driscoll, F. Sesti (2003). "MiRP modulation of K+ channels function is an ancient mechanism conserved across phyla". Biophys. J. 84(2), 414A.
  48. Sesti F., S. Rajan, R. Gonzalez-Colaso, N. Nikolaeva, S.A.N. Goldstein (2003). "MVP, a voltage-gated K+ channel from the third kingdom: Hyperpolarization moves S4 inward to open the pore". Biophys. J. 84(2), 8A-9A.
  49. Sesti F., T. Shih, N. Nikolaeva, S.A.N. Goldstein (2001). "Immunity to K1 killer toxin: internal TOK1 blockade". Cell, 105, 637-44. Featured in: Science (Editor's choice vol 292 page 2401)
  50. Abbott G.W., S.A.N. Goldstein, F. Sesti (2001). "Do all voltage-gated potassium channels employ MiRPs?" Editorial Circulation Res. 88:981-983
  51. Sesti F., T.M. Shih, N. Nikoleva, S.A.N. Goldstein (2001). "The basis for immunity to killer toxin: channel block". Biophys. J. 80(1), 446A.
  52. Sesti F., G.W. Abbott, K.T. Murray, S. Sakasena, P.J. Schwartz, S.G. Priori, D.M. Roden, A.L. George jr., S.A.N. Goldstein (2000) "A common polymorphism associated with cardiac arrhythmia increases sensitivity to a common antibiotic". Proc. Natl. Acad. Sci. USA, 97(19), 10613-18
  53. Sesti F., K.K. Tai, S.A.N. Goldstein (2000). "MinK endows the IKs potassium channel pore with sensitivity to internal Tetraethylammonium". Biophys. J., 79, 1369-78
  54. Shih T.M., A. Ahmed, F. Sesti, N. Ilan, S.L. Sturley, S.A.N. Goldstein (2000). "Viral killer toxin acts via activation of TOK1 potassium channels". Biophys. J 78(1), 205A.
  55. Sesti F., G.W. Abbott, J. Wei, D.M. Roden, A. George, S.A.N. Goldstein (2000). "MiRP1 mutant associated with quinidine-induced cardiac arrhythmia supports a genetic contribution to" acquired" disease". Biophys. J. 78(1), 204A.
  56. Sesti F., G.W. Abbott, J. Wei, D.M. Roden, A. George, S.A.N. Goldstein (1999). "Function of A116V-MiRP1: A missense mutation associated with acquired arrhythmia". CIRCULATION 100(18), 495.
  57. Wei J., G.W. Abbott, F. Sesti, S.A.N. Goldstein, P.J. Schwartz, S. Saksena, K.T. Murray, D.M. Roden, A. George (1999). "Prevalence of KCNE2 (Mirp1) mutations in acquired long QT syndrome". CIRCULATION 100(18), 495.
  58. Ahmed A.*, F. Sesti*, N. Ilan, T. M. Shih, S. L. Sturley, S. A. N. Goldstein (1999). "A molecular target for viral killer toxin: TOK1 potassium channels". Cell, 99, 283-91. (*co-first author) Cover article
  59. Boenigk W., J. Bradley, F. Muller, F. Sesti, I. Boekhoff, G.V. Ronnet, U.B. Kaupp, S. Frings (1999). "The native rat olfactory nucleotide-gated channel is composed of three subunits". J. Neurosci, 1999, 19, 5332-5347
  60. Abbot G.W.*, F. Sesti*, I. Splawsky*, M.E. Buck, M. H. Lehmann, K. W. Timothy, M. T. Keating, S. A. N. Goldstein (1999). "MiRP1 forms Ikr potassium channels with HERG and is associated with cardiac arrhythmia". Cell, 97, 175-187 (*co-first author)
  61. Sesti F., G.W. Abbott, M. Buck, S.A.N. Goldstein (1999). "MiRPs: Small transmembrane proteins that dictate the essential functional characteristics of mixed ion channel complexes". Biophys. J 76(1), A15.
  62. Abbott G.W., F. Sesti, M. Buck, S.A.N. Goldstein (1999). "A new superfamily of small ion channel subunits". Biophys. J. 76(1), A75.
  63. Sesti F. and S.A.N. Goldstein (1998). "Single-channel characteristics of wildtype Iks channels and channels formed with two MinK mutants that cause long QT syndrome". J. Gen. Physiol., 112/6, 651-63. Cover article
  64. Sesti F. and S.A.N. Goldstein (1998). "I-Ks channels: minK/KvLQT1 heteromultimers have a larger unitary conductance than homomeric KvLQT1 channels". Biophys. J. 74(2), A346.
  65. Frings S., C. Dzeja, W. Bonigk, F. Muller, J. Bradley, F. Sesti, U.B. Kaupp (1998). "cAMP-gated channels of olfactory sensory neurons: Subunit composition; Ca2+ permeation, and modulation of ligand sensitivity". EUROPEAN JOURNAL OF NEUROSCIENCE 10, 358.
  66. Mueller F., W. Boenigk, F. Sesti, S. Frings (1998). "Phosphorylation of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity". J. Neurosci, 1998, 18/1: 164-173.
  67. Sesti F. and E. Eismann (1997). "Gating of cyclic-nucleotide gated channels by voltage and permeant ion". Biophys. J. 72(2), WPMB7.
  68. Sesti F., M. Nizzari, V. Torre (1996). "The effect of changing the temperature on the ionic permeation through the cyclic-GMP gated channel from vertebrate photoreceptors". Biophys. J., 70(6), 2616-2639.
  69. Bucossi G., E. Eisman, F. Sesti, M. Nizzari, M. Seri, U.B. Kaupp, V. Torre (1996). "Time-dependent current decline in cyclic GMP-gated channels caused by point mutations in the pore region". J. Physiol., 493.2, 409-418.
  70. Bucossi G., E. Eismann, F. Sesti, M. Nizzari, M. Seri, U.B. Kaupp, V. Torre (1996). "The single channel conductance of the cyclic GMP-gated channel from vertebrate rods". J. Physiol. 491, 146-7
  71. Bucossi G., E. Eismann, F. Sesti, M. Nizzari, M. Seri, U.B. Kaupp, V. Torre (1996). "Gating and permeation through the cyclic GMP-gated channel of vertebrate rods are tightly coupled". J. Physiol. 491, S9.
  72. Bucossi G., E. Eismann, F. Sesti, M. Nizzari, M. Seri, U.B. Kaupp, V. Torre (1996). "The cyclic GMP-gated channel from vertebrate rods has multiple open states". Biophys. J., 70(2), WAMF8.
  73. Sesti F., E. Eismann, S. Frings, U.B. Kaupp (1996). "Three distinct gating modes control cyclic nucleotide-gated channels". Progress in Biophysics and Molecular Biology, 113.
  74. Korschen H.G., M. Illing, R. Seifert, F. Sesti, A. Williams, S. Gotzes, C. Colville, F. Muller, A. Dose, M. Godde, L. Molday, U.B. Kaupp, R. Molday (1995). "A 240 kDa protein represents the complete B subunit of the cyclic nucleotide-gated channel from rod photoreceptors". Neuron, 15, 627-636
  75. Sesti F., E. Eisman, U.B. Kaupp, M. Nizzari, V. Torre (1995). "The multi-ion nature of the cGMP-gated channel from vertebrate rods". J. Physiol., 487.1, 17-36.
  76. Sesti F. and V. Torre (1994). "Enthalpic and entropic contribution to the Ionic Selectivity of the Cyclic-GMP Activated Channel in Vertebrate Photoreceptors". Biophys. J. 66(2), A355.
  77. Sesti F., M. Straforini, T.D. Lamb, V. Torre (1994). "Gating, selectivity and blockage of single channels activated by cyclic GMP in retinal rods of the tiger salamander". J. Physiol., 474, 203-222.
  78. Nizzari M., Sesti F., Giraudo M.T., Virginio C., Cattaneo A., V. Torre (1993). "Single-channels properties of a cloned channel activated by cGMP". Proc. R. Soc. Lond. B, 254, 69-74.
  79. Sesti F. and V. Torre (1993). "The Blocking Effect of Ca2+ and Mg2+ on the cGMP Activated Current in Retinal Rods". Biophys. J. 64(2), A17.
  80. Torre V., M. Straforini, F. Sesti, T.D. Lamb (1992). "Different channel-gating properties of two classes of cyclic GMP-activated channel in vertebrate photoreceptors". Proc. R. Soc. Lond. B., 250, 209-215.
  81. Sesti F., M. Straforini, L. Spadavecchia, V. Torre (1992). "Properties of single channels activated by cGMP in retinal rods". Experimental Eye Research 55, 71.
  82. Torre V., Sesti F., L. Spadavecchia (1992). "The Effect of Temperature on the Cyclic-GMP Gated Channel from Rod Outer Segments of the Tiger Salamander". FASEB J. 6(1), A427.